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Codeine and Kids

Codeine! The analgesic of choice for head injury patients for junior house staff those many moons ago!  It wasn’t really a choice, we weren’t allow to use morphine because it was dangerous! But what do we know now….? Codeine is a pro-drug that gets broken down to morphine.  So all those years ago we were delivering … Continue reading

FDA warns about codeine! What about hydrocodone?

Codeine is a prodrug.  It gets broken down to other drugs to provide pain relief.  10% of codeine gets broken down to morphine in a “normal” individual.  The enzyme that does this is located in the liver, cytochrome P450 2D6 (CYP2D6).  This has been known since the 1980s. Well, so what? 5-10% of Caucasians lack … Continue reading

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